William Harvey

Lived 1578 to 1657.

William Harvey was the first person to correctly describe blood’s circulation in the body.

He showed that arteries and veins form a complete circuit. The circuit starts at the heart and leads back to the heart.

The heart’s regular contractions drive the flow of blood around the whole body.

Early Life and Education

William Harvey was born on April 1, 1578 in Folkstone, England.

He was born into a relatively wealthy family: his father, Thomas Harvey, was a successful businessman who became Mayor of Folkstone; his mother, Joane Hawke, gave birth to nine children, of whom William was the eldest.

William Harvey started his education at a small elementary school in Folkstone, moving on at the age of 10 to the elite King’s Grammar School in Canterbury.

While attending King’s Grammar School he lived in his uncle’s home and spent most of his school time learning the classics – Latin was essential throughout Europe for academic and legal work.

Medical Student

Cambridge
In 1593, aged 15, the young Harvey enrolled as a medical student at the University of Cambridge; he had won a scholarship to pay his living costs and tuition fees there for six years. In the last two years of the six-year scholarship, he spent some time at universities in France, Germany and Italy, learning more about science and medicine.

Padua
In 1599, aged 21, he enrolled at the University of Padua in Italy, which was acclaimed for its medical and anatomy courses. (Interestingly, when Harvey arrived in Padua, Galileo Galilei had already been there for seven years, teaching mathematics, physics and astronomy.)

The greatest influence on Harvey at Padua University was his teacher, Hieronymus Fabricius, who was a skilled anatomist and surgeon. The two became friends and Harvey learned from Fabricius that dissection offered a route to better understanding of the human body.

Fabricius had discovered valves in human veins in 1574, although he did not publish his discovery until 1603.

An Outstanding Student
In 1602, Harvey graduated as a Doctor of Medicine from Padua. His teachers wrote on his diploma:

“[Harvey] had conducted himself so wonderfully well in the examination, and had shown such skill, memory and learning that he had far surpassed even the great hopes which his examiners had formed of him. They decided therefore that he was skilful, expert, and most efficiently qualified both in arts and medicine…”

HIERONYMUS FABRICIUS

Shakespearean Times
In terms of historical context, while Harvey was studying in Padua, William Shakespeare was completing Hamlet, which most critics regard as his greatest work.

William Harvey’s Work

Harvey returned to England in 1602. On his return, the University of Cambridge awarded him a Doctor of Medicine degree, adding to the one he already had from Padua. He then moved to London to work as a physician.

He joined the College of Physicians in 1604, becoming a Fellow of the College in 1607 and Head Physician at St Bartholomew’s Hospital.

In 1615, aged 37, Harvey became the College of Physicians’ Lumleian Lecturer, specializing in teaching surgery. In this role, he gave an annual series of lectures, while continuing his work at St Bartholemew’s Hospital.

By the time he was 40, Harvey had won recognition as the best physician in London and was appointed as physician to the king – King James – in 1618.

In 1632, aged 54, he became physician to King Charles.

The Circulation of Blood

Harvey was able to make his discoveries because he ignored medical text books, preferring his own observations and the deductions he made during dissections of animals.

Remarkably, western medical beliefs – and theories about blood and circulation – had advanced little since Galen wrote his medical textbooks in Rome 1400 years earlier.

“I have often wondered and even laughed at those who fancied that everything had been so consummately and absolutely investigated by an Aristotle or a Galen or some other mighty name, that nothing could by any possibility be added to their knowledge.”

WILLIAM HARVEY

In 1628, aged 50, Harvey published his masterpiece – usually referred to as De Moto Cordis – the Motion of the Heart. Its full title in English is: Anatomical Studies on the Motion of the Heart and Blood in Animals.

In De Moto Cordis Harvey became the first person to accurately describe the function of the heart and the circulation of blood around the body.

William Harvey discusses his theory of blood circulation with King Charles the First.

Harvey’s knowledge came from observations he made of blood flowing through the veins and arteries of living animals that he cut open. Through modern eyes, his living dissections look cruel, and there were no anesthetics in Harvey’s time. Nevertheless, it is how we arrived at an understanding of blood and its circulation in the body.

Harvey finally put to rest some of the errors Galen had made so many years earlier. Yet Galen did not get everything wrong. Some of his teachings were useful. At one point Galen had to flee from Rome because his methods threatened the careers of Rome’s quack physicians.

Ironically, in correcting Galen’s mistakes about blood and circulation, Harvey himself ran into trouble with Europe’s latest crop of quack physicians, who were making great use of Galen’s worthless blood letting methods. While not forced to flee for his life, Harvey’s own medical practice declined because of the barrage of criticism he took from physicians.

In fact, even 200 years after Harvey’s death, Galen’s blood letting was still being used, probably shortening the life of Ada Lovelace.

When he was later asked about he possibility of carrying out further experiments, Harvey (we have slightly modernized his English) said:

“You know very well the storm my previous research caused. It is often better to grow wise in private at home, than to publish what you have amassed with infinite labor, to stir up storms that may rob you of peace and quiet for the rest of your days.”

WILLIAM HARVEY

Despite the storms he had caused, the majority of respectable anatomists saw the truth of Harvey’s work within his lifetime.

In 1651, aged 73, Harvey donated money anonymously to allow the College of Physicians to have a new library built. The identity of the donor became known and the College built a statue in Harvey’s honor.

Harvey’s Main Conclusions about Blood Circulation

Harvey showed for the first time that the arteries and veins circulate blood through the whole body. He showed that the heart’s beat produces a constant circulation of blood through the whole body. He refuted many of the then standard beliefs of how the heart and blood system worked, establishing that:

blood in the arteries and the veins is all of the same origin, not manufactured in different parts of the body
the blood sent through the arteries to the tissues is not consumed there
the circulation mechanism is designed for movement of liquid, not air. The blood on the right side, although carrying air, is still blood
the heart is the source of blood movement, not the liver
the heart contracts at the same time as a pulse is felt
the ventricles squeeze blood into the aorta and pulmonary artery
the pulse is not produced by the arteries pulling blood in, but by blood being pushed by the heart into the arteries, enlarging them
there are no vessels in the heart’s septum: all of the blood in the right ventricle goes to the lungs and then through the pulmonary veins to the left ventricle
• Similarly, all of the blood in the left ventricle is sent into the arteries, round by the smaller veins into the venae cavae, and then to the right ventricle again. In this way, the circulation is complete. The blood has come back to where it began its circuit of the body
there is no to-and-fro movement of blood in the veins, but a constant flow of blood to the heart.

The End

William Harvey died in London, aged 79, at the home of one of his brothers, on June 3, 1657. The cause of death was most probably a cerebral hemorrhage. He had no children, and his wife, Elizabeth Browne, died before he did. William Harvey’s grave can be found in the village of Hempstead, in the English county of Essex.

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Wednesday, April 1, 2015

Famous Scientists- William Harvey